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Rub, Rukhsana A.
- Pharmacognostic and Preliminary Phytochemical Screening of Cichorium intybus Linn Seed
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Authors
Affiliations
1 Department of Pharmacognosy, M.C.E. Society’s Allana College of Pharmacy, Pune-411001, MS, IN
1 Department of Pharmacognosy, M.C.E. Society’s Allana College of Pharmacy, Pune-411001, MS, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 977-980Abstract
Cichorium intybus a member of Asteraceae family, is a perennial herb cultivated throughout India. It is commonly known as Chicory. It has been reported to have antifungal, antitibacterial, hypoglycemic and hepatoprotective activity in various traditional systems of medicine. It is also found to have antineoplstic, antioxidant, analgesic and sedative activity. As the Pharmacognostic and Phytochemical data on the seeds of Cichorium intybus have not been reported previously, various pharmacognostic parameters like, examination of macroscopical, microscopical characters, ash values, extractive values, foreign organic matter and LOD were studied with the aim of establishing monograph for this species. Phytochemical screening included qualitative chemical examination and Thin layer chromatography of the detected phytoconstituents. Microscopical characters showed the presence of parenchyma, single layered tangentially elongated epidermis, well defined endosperm and papus. Powder characteristic also showed the presence of epidermal cells, papus and endosperm. The total ash, water soluble ash and acid insoluble ash were found to be 9.2%w/w, 1.1%w/w, 1.4%w/w respectively. The moisture content was found to be 7 w/w. Water, Alcohol and Chloroform soluble extractive values were found to be 12.2%w/w,13.4%w/w, 1.2%w/w respectively. Preliminary phytochemical investigation of aqueous and methanolic extract of seeds of cichorium intybus revealed the presence of Carbohydrates, Alkaloids, Tannins and Flovonoids which were further confirmed by thin layer chromatography with the Rf values as 0.94,0.75 and 0.78 for carbohydrates, alkaloids, flavonoids and 0.81 and 0.90 for tannins and flavonoids respectively.Keywords
Cichorium intybus, Chicory, Phytochemical Investigation, Pharmacognostic Evaluations, Rf Value.- Pharmacognostic and Phytochemical Evaluation of Quirivelia frutescens (Apocynaceae)
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The total ash, acid insoluble and water-soluble ash were found to be within the limit as compared to other plants belonging to Apocyanaceae family. The preliminary phytochemical studies indicated the presence of alkaloids and tannins. Phytochemical analysis, like TLC, UV, IR NMR, GCMS, were carried out by using the extract of stem. In TLC, the Rf value was found to be 0.77, which is near to many alkaloids. In C13 NMR, the peak showed the presence of unsaturation between conjugated carbon of alkaloid and steroid group and saturated ring substituted with aliphatic chain. GCMS study showed the presence of eight chemicals constituent in the extract. In UV, the λmax was found between 331 to 337 nm and peak indicated the presence of unsaturation.
Thus, from the above study, it can be concluded that the plant Quirivalia fructescens, has rich content of alkaloid, steroid and tannins.
Authors
Affiliations
1 M.C.E. Society’s Allana College of Pharmacy, Pune-01, MS, IN
1 M.C.E. Society’s Allana College of Pharmacy, Pune-01, MS, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 4 (2009), Pagination: 509-512Abstract
Quirivelia frutescens (Apocynaceae) also known as kalidudhi or shymlata is much branched twining shrub of West Bengal. It is used by natives as wound healing, digestive etc. However the plant is not much explored pharmacognostically and phytochemically, therefore the aim of this study was to evaluate pharmacognostic and phytochemical characteristics of plant Quirivelia fructescens. Microscopy of leaves showed distinct bicollateral vascular bundle,single layer of palisade, and well defined anomocytic stomata. Presence of calcium oxalate crystal in the form of thin pointed needle and xylem vessels with circular bordered pits were observed in the stem.The total ash, acid insoluble and water-soluble ash were found to be within the limit as compared to other plants belonging to Apocyanaceae family. The preliminary phytochemical studies indicated the presence of alkaloids and tannins. Phytochemical analysis, like TLC, UV, IR NMR, GCMS, were carried out by using the extract of stem. In TLC, the Rf value was found to be 0.77, which is near to many alkaloids. In C13 NMR, the peak showed the presence of unsaturation between conjugated carbon of alkaloid and steroid group and saturated ring substituted with aliphatic chain. GCMS study showed the presence of eight chemicals constituent in the extract. In UV, the λmax was found between 331 to 337 nm and peak indicated the presence of unsaturation.
Thus, from the above study, it can be concluded that the plant Quirivalia fructescens, has rich content of alkaloid, steroid and tannins.
Keywords
Quirivelia frutescens, Apocyanaceae, Rf Value, Anomocytic Stomata, Alkaloid, Steroids, Tannins.- Dissolution Enhancement of Ezetimibe by Solid Dispersion
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Authors
Aaisha N. Sagri
1,
Rukhsana A. Rub
1,
Anita S. Kulkarni
2,
Indrajeet Gonjari
2,
Dhananjay S. Saindane
3,
Umair I. Shaikh
4
Affiliations
1 Allana College of Pharmacy, Pune, Maharashtra, IN
2 Govt. College of Pharmacy, Karad, Maharashtra, IN
3 College of Pharmacy, Dhule, Maharashtra, IN
4 Luqman College of Pharmacy, Gulbarga, Maharashtra, IN
1 Allana College of Pharmacy, Pune, Maharashtra, IN
2 Govt. College of Pharmacy, Karad, Maharashtra, IN
3 College of Pharmacy, Dhule, Maharashtra, IN
4 Luqman College of Pharmacy, Gulbarga, Maharashtra, IN